pfut-1 GDP-fucose protein O-fucosyltransferase 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pfut-1
Official Full Name: GDP-fucose protein O-fucosyltransferase 1
Primary source: WormBase:WBGene00015793
Locus tag: CELE_C15C7.7
See related: AllianceGenome:WB:WBGene00015793
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables peptide-O-fucosyltransferase activity. Involved in protein O-linked fucosylation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Dowling-Degos disease. Orthologous to human POFUT1 (protein O-fucosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide-O-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-O-fucosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked fucosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein O-linked fucosylation	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_741744.2

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The following sections contain reference sequences that belong to a specific genome build. Explain