cuc-1 Copper transport protein ATOX1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cuc-1
Official Full Name: Copper transport protein ATOX1
Primary source: WormBase:WBGene00000835
Locus tag: CELE_ZK652.11
See related: AllianceGenome:WB:WBGene00000835
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables copper chaperone activity. Involved in copper ion transport. Located in cytosol. Is expressed in hyp5; hyp6; hyp7 syncytium; and intestine. Orthologous to human ATOX1 (antioxidant 1 copper chaperone). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cuc-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (7860466..7860985, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Caenorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell migration.
Title: The Caenorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell migration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK652.1 (e-PCR)
- UniSTS:316319

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables copper chaperone activity	IBA Inferred from Biological aspect of Ancestor more info
enables copper chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallochaperone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in copper ion import	TAS Traceable Author Statement more info	PubMed
involved_in copper ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in copper ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion transport	IEA Inferred from Electronic Annotation more info
involved_in metal ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Copper transport protein ATOX1

NP_498707.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7860466..7860985 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066306.9 → NP_498707.1 Copper transport protein ATOX1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498707.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EE41

Conserved Domains (1) summary

cd00371
Location:9 → 64

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...