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    inx-1 Innexin [ Caenorhabditis elegans ]

    Gene ID: 180968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-1
    Official Full Name
    Innexin
    Primary source
    WormBase:WBGene00002123
    Locus tag
    CELE_C16E9.4
    See related
    AllianceGenome:WB:WBGene00002123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in gap junction. Is expressed in neurons and pm1. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (6943735..6956399, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DUF2045 domain containing protein;Transposase Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OFF-responses of interneurons optimize avoidance behaviors depending on stimulus strength via electrical synapses. Hori S, et al. PLoS Genet, 2018 Jun. PMID 29939997, Free PMC Article
    2. C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program. Jiang J, et al. Nat Commun, 2022 May 19. PMID 35589790, Free PMC Article
    3. Innexins in C. elegans. Starich T, et al. Cell Commun Adhes, 2001. PMID 12064609
    4. Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system. Starich TA, et al. Neural Dev, 2009 May 11. PMID 19432959, Free PMC Article
    5. Six innexins contribute to electrical coupling of C. elegans body-wall muscle. Liu P, et al. PLoS One, 2013. PMID 24130800, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Innexin
    NP_001024407.1
    • Confirmed by transcript evidence
    NP_741826.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6943735..6956399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171716.5 → NP_741826.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741826.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17394, T2DKY3
      Conserved Domains (1) summary
      pfam00876
      Location:19 → 366
      Innexin; Innexin

    2. NM_001029236.3 → NP_001024407.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024407.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG52, T2DKY3
      Conserved Domains (1) summary
      pfam00876
      Location:19 → 366
      Innexin; Innexin

    RNA

    1. NR_131721.1 RNA Sequence

      Status: REVIEWED

    2. NR_131722.1 RNA Sequence

      Status: REVIEWED

    3. NR_131723.1 RNA Sequence

      Status: REVIEWED

    4. NR_131724.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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