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    tmc-1 Transmembrane channel-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 188483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmc-1
    Official Full Name
    Transmembrane channel-like protein 1
    Primary source
    WormBase:WBGene00020490
    Locus tag
    CELE_T13G4.3
    See related
    AllianceGenome:WB:WBGene00020490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables sodium channel activity. Involved in detection of stimulus involved in sensory perception; monoatomic ion transmembrane transport; and sensory perception of chemical stimulus. Located in neuronal cell body; non-motile cilium; and plasma membrane. Is expressed in body wall musculature; neurons; vulval muscle; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to several human genes including TMC3 (transmembrane channel like 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Sequence:
    Chromosome: X; NC_003284.9 (1163159..1177172)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein quiver Neighboring gene Hcy-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TMC-1 attenuates C. elegans development and sexual behaviour in a chemically defined food environment. Zhang L, et al. Nat Commun, 2015 Feb 19. PMID 25695879
    2. The Caenorhabditis elegans tmc-1 is involved in egg-laying inhibition in response to harsh touch. Kaulich E, et al. MicroPubl Biol, 2021. PMID 34414364, Free PMC Article
    3. Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels. Tang YQ, et al. Neuron, 2020 Jul 8. PMID 32325031, Free PMC Article
    4. Characterization of TMC-1 in C. elegans sodium chemotaxis and sodium conditioned aversion. Dao J, et al. BMC Genet, 2020 Mar 30. PMID 32228447, Free PMC Article
    5. Sensing pH with TMCs. Spalthoff C, et al. Neuron, 2016 Jul 6. PMID 27387645

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structures of the TMC-1 complex illuminate mechanosensory transduction.
      Title: Structures of the TMC-1 complex illuminate mechanosensory transduction.
    2. Characterization of TMC-1 in C. elegans sodium chemotaxis and sodium conditioned aversion.
      Title: Characterization of TMC-1 in C. elegans sodium chemotaxis and sodium conditioned aversion.
    3. Study found that the C. elegans TMC-1 is expressed in both neurons and muscle cells, while TMC-2 is exclusively expressed in muscle cells. TMC proteins modulate egg laying and membrane excitability through a background leak conductance.
      Title: TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans.
    4. Ectopic expression of TMC-1 confers alkaline sensitivity to alkali-insensitive cells
      Title: TMC-1 Mediates Alkaline Sensation in C. elegans through Nociceptive Neurons.
    5. TMC-1 has a role in regulating C. elegans development and sexual behaviour in a chemically defined food environment
      Title: TMC-1 attenuates C. elegans development and sexual behaviour in a chemically defined food environment.
    6. TMC-1 is both necessary for salt sensation in vivo and sufficient to generate a sodium-sensitive channel in vitro, identifying it as a probable ionotropic sensory receptor
      Title: tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of stimulus involved in sensory perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of chemical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane channel-like protein 1
    NP_508221.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1163159..1177172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075820.9 → NP_508221.3  Transmembrane channel-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508221.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3KZG3, G4S885
      Conserved Domains (1) summary
      pfam07810
      Location:672 → 778
      TMC; TMC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3KZG3.2

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