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    unc-34 VASP tetramerization domain-containing protein;VASP_tetra domain-containing protein;WH1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190098, updated on 4-Jan-2025

    Summary

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    Official Symbol
    unc-34
    Official Full Name
    VASP tetramerization domain-containing protein;VASP_tetra domain-containing protein;WH1 domain-containing protein
    Primary source
    WormBase:WBGene00006770
    Locus tag
    CELE_Y50D4C.1
    See related
    AllianceGenome:WB:WBGene00006770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables signaling receptor binding activity. Involved in axon development; gonad morphogenesis; and positive regulation of locomotion. Located in several cellular components, including cell junction; cell leading edge; and filopodium tip. Is expressed in epithelial cell and nervous system. Used to study tauopathy. Orthologous to several human genes including ENAH (ENAH actin regulator) and EVL (Enah/Vasp-like). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See unc-34 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (982706..996914)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Drf_GBD domain-containing protein Neighboring gene Piwi domain-containing protein;Piwi-like protein ergo-1 Neighboring gene BTB domain-containing protein;SAM domain-containing protein Neighboring gene UPF0496 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of C. elegans Ena/VASP homolog UNC-34 in neuronal polarity and motility. Fleming T, et al. Dev Biol, 2010 Aug 1. PMID 20452341, Free PMC Article
    2. A two-step actin polymerization mechanism drives dendrite branching. Shi R, et al. Neural Dev, 2021 Jul 19. PMID 34281597, Free PMC Article
    3. SUT-1 enables tau-induced neurotoxicity in C. elegans. Kraemer BC, et al. Hum Mol Genet, 2007 Aug 15. PMID 17576746
    4. Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia cross-linker fascin. Harker AJ, et al. Mol Biol Cell, 2019 Mar 21. PMID 30601697, Free PMC Article
    5. Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Colón-Ramos DA, et al. Science, 2007 Oct 5. PMID 17916735, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the C. elegans Ena/VASP homolog UNC-34 has a role in neuronal polarity and motility
      Title: The role of C. elegans Ena/VASP homolog UNC-34 in neuronal polarity and motility.
    2. UNC-115/abLIM and UNC-34/Enabled control growth cone filopodia formation, possibly in parallel to Arp2/3.
      Title: The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans.
    3. Embryos lacking UNC-34 display subtle defects in the leading edges of migrating epidermal cells but undergo normal epidermal morphogenesis.
      Title: C. elegans Enabled exhibits novel interactions with N-WASP, Abl, and cell-cell junctions.
    4. Enabled molecule UNC-34 defines a fourth partially redundant pathway that acts in parallel to Rac/MIG-15 signaling in axon pathfinding.
      Title: Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal/ventral axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in filopodium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    VASP tetramerization domain-containing protein;VASP_tetra domain-containing protein;WH1 domain-containing protein
    NP_001024254.1
    • Confirmed by transcript evidence
    NP_001300273.1
    • Confirmed by transcript evidence
    NP_001300274.1
    • Confirmed by transcript evidence
    NP_001300275.1
    • Confirmed by transcript evidence
    NP_001300276.1
    • Confirmed by transcript evidence
    NP_001300277.1
    • Confirmed by transcript evidence
    NP_503360.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      982706..996914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070959.8 → NP_503360.4  WH1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503360.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG53
      Conserved Domains (2) summary
      cd01207
      Location:6 → 114
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:423 → 448
      VASP_tetra; VASP tetramerisation domain

    2. NM_001313344.4 → NP_001300273.1  WH1 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AW41
      Conserved Domains (1) summary
      cl17171
      Location:6 → 114
      PH-like; Pleckstrin homology-like domain

    3. NM_001313345.3 → NP_001300274.1  WH1 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYC9
      Conserved Domains (2) summary
      pfam08776
      Location:413 → 438
      VASP_tetra; VASP tetramerisation domain
      cl17171
      Location:1 → 104
      PH-like; Pleckstrin homology-like domain

    4. NM_001029083.5 → NP_001024254.1  WH1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0C7
      Conserved Domains (1) summary
      cl17171
      Location:1 → 100
      PH-like; Pleckstrin homology-like domain

    5. NM_001313346.3 → NP_001300275.1  VASP tetramerization domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT36
      Conserved Domains (1) summary
      pfam08776
      Location:282 → 307
      VASP_tetra; VASP tetramerization domain

    6. NM_001313347.3 → NP_001300276.1  VASP tetramerization domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVD7
      Conserved Domains (1) summary
      pfam08776
      Location:164 → 189
      VASP_tetra; VASP tetramerization domain

    7. NM_001313348.3 → NP_001300277.1  VASP_tetra domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASI4
      Conserved Domains (1) summary
      pfam08776
      Location:118 → 143
      VASP_tetra; VASP tetramerisation domain
    Nucleotide Protein
    Heading Accession and Version

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