U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    exc-4 Chloride intracellular channel exc-4 [ Caenorhabditis elegans ]

    Gene ID: 173314, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    exc-4
    Official Full Name
    Chloride intracellular channel exc-4
    Primary source
    WormBase:WBGene00001365
    Locus tag
    CELE_Y105E8A.22
    See related
    AllianceGenome:WB:WBGene00001365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chloride channel activity. Involved in epithelial cell development and regulation of tube size. Located in apical junction complex; apical plasma membrane; and lysosome. Is expressed in several structures, including amphid sheath cell; excretory system; pharyngeal muscle cell; rectum; and vulva. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Orthologous to several human genes including CLIC2 (chloride intracellular channel 2) and CLIC4 (chloride intracellular channel 4). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See exc-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (14511431..14518719, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein;TFIIIC_sub6 domain-containing protein Neighboring gene ncRNA Neighboring gene Tight junction protein ZO-1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A metazoan-specific C-terminal motif in EXC-4 and Gα-Rho/Rac signaling regulate cell outgrowth during tubulogenesis in C. elegans. Arena AF, et al. Development, 2022 Dec 15. PMID 36398726, Free PMC Article
    2. Chloride intracellular channel (CLIC) proteins function as fusogens. Manori B, et al. Nat Commun, 2024 Mar 7. PMID 38453905, Free PMC Article
    3. A C. elegans CLIC-like protein required for intracellular tube formation and maintenance. Berry KL, et al. Science, 2003 Dec 19. PMID 14684823
    4. Mapping functional domains of chloride intracellular channel (CLIC) proteins in vivo. Berry KL, et al. J Mol Biol, 2006 Jun 23. PMID 16737711
    5. Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC. Littler DR, et al. Proteins, 2008 Apr. PMID 17985355

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. distinguishing features of exc-4 structure determined from crystal structure are described
      Title: Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC.
    2. The putative transmembrane (PTM) region thus provides both targeting information and Chloride intracellular channel functional specificity, possibly adapting GST-type proteins to function as ion channels.
      Title: Mapping functional domains of chloride intracellular channel (CLIC) proteins in vivo.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of tube size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Chloride intracellular channel exc-4
    NP_740950.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14511431..14518719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170954.3 → NP_740950.2  Chloride intracellular channel exc-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740950.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8WQA4
      Conserved Domains (3) summary
      TIGR00862
      Location:17 → 243
      O-ClC; intracellular chloride channel protein
      cd03198
      Location:115 → 248
      GST_C_CLIC; C-terminal, alpha helical domain of Chloride Intracellular Channels
      cd03061
      Location:14 → 109
      GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WQA4.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools