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    zwl-1 Protein zwilch homolog [ Caenorhabditis elegans ]

    Gene ID: 171798, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zwl-1
    Official Full Name
    Protein zwilch homolog
    Primary source
    WormBase:WBGene00021460
    Locus tag
    CELE_Y39G10AR.2
    See related
    AllianceGenome:WB:WBGene00021460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of mitotic spindle pole body separation; positive regulation of protein localization to kinetochore; and protein localization to kinetochore involved in kinetochore assembly. Located in kinetochore. Part of RZZ complex. Orthologous to human ZWILCH (zwilch kinetochore protein). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See zwl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (2402230..2409999)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Synaptic defective enhancer 1 Neighboring gene Histone-lysine N-methyltransferase, H3 lysine-79 specific Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein Neighboring gene Electron transfer flavoprotein subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Disordered Spindly C-terminus Interacts with RZZ Subunits ROD-1 and ZWL-1 in the Kinetochore through the Same Sites in C. Elegans. Henen MA, et al. J Mol Biol, 2021 Feb 19. PMID 33450249, Free PMC Article
    2. Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment. Pereira C, et al. Curr Biol, 2018 Nov 5. PMID 30415699, Free PMC Article
    3. Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly. Gama JB, et al. J Cell Biol, 2017 Apr 3. PMID 28320824, Free PMC Article
    4. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Dumont J, et al. Nat Cell Biol, 2010 Sep. PMID 20729837, Free PMC Article
    5. Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes. Pitayu-Nugroho L, et al. Nat Commun, 2023 Jul 7. PMID 37419936, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitotic spindle pole body separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic spindle pole body separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to kinetochore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore involved in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RZZ complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RZZ complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein zwilch homolog
    NP_001249150.1
    • Confirmed by transcript evidence
    NP_001249151.1
    • Confirmed by transcript evidence
    NP_001293318.1
    • Confirmed by transcript evidence
    NP_001293319.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2402230..2409999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001262222.4 → NP_001249151.1  Protein zwilch homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XP9
      Conserved Domains (1) summary
      pfam09817
      Location:27 → 628
      DUF2352; Uncharacterized conserved protein (DUF2352)

    2. NM_001262221.3 → NP_001249150.1  Protein zwilch homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A061AD83, A0A061AEC9, H2KZV1, Q95XP9
      Conserved Domains (1) summary
      pfam09817
      Location:27 → 630
      DUF2352; Uncharacterized conserved protein (DUF2352)

    3. NM_001306389.3 → NP_001293318.1  Protein zwilch homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XP9
      Conserved Domains (1) summary
      pfam09817
      Location:7 → 309
      DUF2352; Uncharacterized conserved protein (DUF2352)

    4. NM_001306390.3 → NP_001293319.1  Protein zwilch homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XP9
      Conserved Domains (1) summary
      pfam09817
      Location:7 → 307
      DUF2352; Uncharacterized conserved protein (DUF2352)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XP9.1

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