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    dsl-2 Delta-like protein [ Caenorhabditis elegans ]

    Gene ID: 176938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dsl-2
    Official Full Name
    Delta-like protein
    Primary source
    WormBase:WBGene00001104
    Locus tag
    CELE_W09G12.1
    See related
    AllianceGenome:WB:WBGene00001104
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Notch binding activity. Predicted to be involved in cell fate specification. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dsl-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (1202651..1204970, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 20 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sphingosine Phosphate Lyase Neighboring gene pseudo Neighboring gene Delta-like protein dsl-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A "latent niche" mechanism for tumor initiation. McGovern M, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19564624, Free PMC Article
    2. The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Chen N, et al. Dev Cell, 2004 Feb. PMID 14960273
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Delta-like protein
    NP_500052.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1202651..1204970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067651.7 → NP_500052.1  Delta-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45203
      Conserved Domains (1) summary
      smart00051
      Location:102 → 164
      DSL; delta serrate ligand
    Nucleotide Protein
    Heading Accession and Version

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