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    pot-3 Protection of telomeres protein 1 ssDNA-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pot-3
    Official Full Name
    Protection of telomeres protein 1 ssDNA-binding domain-containing protein
    Primary source
    WormBase:WBGene00007065
    Locus tag
    CELE_3R5.1
    See related
    AllianceGenome:WB:WBGene00007065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable single-stranded telomeric DNA binding activity. Predicted to be located in chromosome, telomeric region and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pot-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (13780215..13781133)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase parkin;RBR-type E3 ubiquitin transferase;Ubiquitin-like domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 29 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Raices M, et al. Cell, 2008 Mar 7. PMID 18329362
    2. POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang. Yu X, et al. Nucleic Acids Res, 2023 Jan 25. PMID 36583365, Free PMC Article
    3. The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans. Meier B, et al. EMBO J, 2009 Nov 18. PMID 19779462, Free PMC Article
    4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang.
      Title: POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protection of telomeres protein 1 ssDNA-binding domain-containing protein
    NP_001380122.1
    • Confirmed by transcript evidence
    NP_499848.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13780215..13781133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067447.4 → NP_499848.1  Protection of telomeres protein 1 ssDNA-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFG7
      Conserved Domains (1) summary
      pfam16686
      Location:20 → 175
      POT1PC; ssDNA-binding domain of telomere protection protein

    2. NM_001392236.1 → NP_001380122.1  Protection of telomeres protein 1 ssDNA-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      J7SA53
      Conserved Domains (1) summary
      pfam16686
      Location:20 → 171
      POT1PC; ssDNA-binding domain of telomere protection protein
    Nucleotide Protein
    Heading Accession and Version

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