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    dyf-6 Intraflagellar transport protein 46 homolog [ Caenorhabditis elegans ]

    Gene ID: 3565899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyf-6
    Official Full Name
    Intraflagellar transport protein 46 homolog
    Primary source
    WormBase:WBGene00001122
    Locus tag
    CELE_F46F6.4
    See related
    AllianceGenome:WB:WBGene00001122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in intraciliary transport and non-motile cilium assembly. Located in dendrite and neuronal cell body. Is expressed in ciliated neurons and hypodermis. Orthologous to human IFT46 (intraflagellar transport 46). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dyf-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (10379693..10386508, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene UDENN domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1. Bell LR, et al. Genetics, 2006 Jul. PMID 16648645, Free PMC Article
    2. Reconstitution reveals motor activation for intraflagellar transport. Mohamed MAA, et al. Nature, 2018 May. PMID 29743676, Free PMC Article
    3. Worming your way through the genome. Kuwabara PE. Trends Genet, 1997 Nov. PMID 9385843
    4. Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia. Yi P, et al. Curr Biol, 2017 May 22. PMID 28479320
    5. Mutations affecting the chemosensory neurons of Caenorhabditis elegans. Starich TA, et al. Genetics, 1995 Jan. PMID 7705621, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intraciliary transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane bounded cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Intraflagellar transport protein 46 homolog
    NP_001076767.1
    • Confirmed by transcript evidence
    NP_001076768.1
    • Partially confirmed by transcript evidence
    NP_001076770.1
    • Confirmed by transcript evidence
    NP_001379460.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10379693..10386508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083298.2 → NP_001076767.1  Intraflagellar transport protein 46 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076767.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDH6, G5EF67, Q0G838, Q1KYM3, Q1KYP5, Q20474
      Conserved Domains (1) summary
      pfam12317
      Location:254 → 439
      IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

    2. NM_001083301.4 → NP_001076770.1  Intraflagellar transport protein 46 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0G838
      Conserved Domains (1) summary
      pfam12317
      Location:81 → 266
      IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

    3. NM_001392834.1 → NP_001379460.1  Intraflagellar transport protein 46 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam12317
      Location:103 → 288
      IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

    4. NM_001083299.3 → NP_001076768.1  Intraflagellar transport protein 46 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0G838
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0G838.1

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