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    egl-26 Egg-laying defective protein 26 [ Caenorhabditis elegans ]

    Gene ID: 173392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egl-26
    Official Full Name
    Egg-laying defective protein 26
    Primary source
    WormBase:WBGene00001193
    Locus tag
    CELE_C23H3.1
    See related
    AllianceGenome:WB:WBGene00001193
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acyltransferase activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and vulval development. Located in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including buccal cavity; excretory canal; hermaphrodite gonad; rectum; and vulval cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egl-26 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (69654..71279)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene K Homology domain-containing protein Neighboring gene DUF3810 domain-containing protein Neighboring gene Lactamase_B domain-containing protein;MBL fold metallo-hydrolase;Metallo-beta-lactamase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane localization of the NlpC/P60 family protein EGL-26 correlates with regulation of vulval cell morphogenesis in Caenorhabditis elegans. Estes KA, et al. Dev Biol, 2007 Aug 1. PMID 17560977
    2. The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis. Hanna-Rose W, et al. Dev Biol, 2002 Jan 15. PMID 11784109
    3. Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans. Piano F, et al. Curr Biol, 2002 Nov 19. PMID 12445391
    4. Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis. Dufourcq P, et al. Mol Cell Biol, 2002 May. PMID 11940660, Free PMC Article
    5. Sex determination in the nematode C. elegans: analysis of tra-3 suppressors and characterization of fem genes. Hodgkin J. Genetics, 1986 Sep. PMID 3770465, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutation of conserved serine 275 perturbs the apical membrane localization and the function of the EGL-26 protein
      Title: Membrane localization of the NlpC/P60 family protein EGL-26 correlates with regulation of vulval cell morphogenesis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Egg-laying defective protein 26
    NP_001300512.1
    • Confirmed by transcript evidence
    NP_493652.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      69654..71279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061251.6 → NP_493652.1  Egg-laying defective protein 26 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493652.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AWT5, P91082
      Conserved Domains (1) summary
      cl21534
      Location:164 → 273
      NLPC_P60; NlpC/P60 family

    2. NM_001313583.2 → NP_001300512.1  Egg-laying defective protein 26 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWT5
      Conserved Domains (1) summary
      cl21534
      Location:164 → 272
      NLPC_P60; NlpC/P60 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91082.1

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