vps-51 Vacuolar protein sorting-associated protein 51 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vps-51
Official Full Name: Vacuolar protein sorting-associated protein 51 homolog
Primary source: WormBase:WBGene00015176
Locus tag: CELE_B0414.8
See related: AllianceGenome:WB:WBGene00015176
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables syntaxin binding activity. Involved in negative regulation of dense core granule transport; positive regulation of dense core granule transport; and positive regulation of locomotion involved in locomotory behavior. Part of GARP complex. Is expressed in body wall musculature; intestinal cell; and neurons. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 13. Orthologous to human VPS51 (VPS51 subunit of GARP complex). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vps-51 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (5803956..5807291, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the C. elegans Vps51 subunit, which is conserved in all eukaryotes, was identified.
Title: The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0414.8 (e-PCR)
- UniSTS:308387

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in Golgi vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of dense core granule transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dense core granule transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of EARP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GARP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GARP complex	IEA Inferred from Electronic Annotation more info
part_of GARP complex	IPI Inferred from Physical Interaction more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Vacuolar protein sorting-associated protein 51 homolog

NP_001020972.1

Confirmed by transcript evidence

NP_001370336.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5803956..5807291 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025801.4 → NP_001020972.1 Vacuolar protein sorting-associated protein 51 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020972.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01839

Conserved Domains (3) summary

pfam08700
Location:10 → 92

Vps51; Vps51/Vps67

cl02872
Location:193 → 247

DHQ_Fe-ADH; Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH)

cl19297
Location:50 → 210

Dor1; Dor1-like family
NM_001383151.2 → NP_001370336.1 Vacuolar protein sorting-associated protein 51 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G8XYY4

Conserved Domains (1) summary

pfam08700
Location:10 → 91

Vps51; Vps51/Vps67