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    Pop1 processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 67724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pop1provided by MGI
    Official Full Name
    processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1914974
    See related
    Ensembl:ENSMUSG00000022325 AllianceGenome:MGI:1914974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932434G09Rik
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal and tRNA decay. Predicted to be located in nucleolus. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Human ortholog(s) of this gene implicated in anauxetic dysplasia 2. Orthologous to human POP1 (POP1 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.5), limb E14.5 (RPKM 3.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pop1 in Genome Data Viewer
    Location:
    15 B3.1; 15 14.34 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34495457..34530799)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34495311..34530653)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glutamate rich 5 Neighboring gene reactive intermediate imine deaminase A homolog Neighboring gene STARR-seq mESC enhancer starr_38330 Neighboring gene predicted gene, 22208 Neighboring gene NIPA-like domain containing 2 Neighboring gene RIKEN cDNA 4930413F20 gene Neighboring gene predicted gene, 53873

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. POP1 inhibits MSU-induced inflammasome activation and ameliorates gout. de Almeida L, et al. Front Immunol, 2022. PMID 36225929, Free PMC Article
    2. The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease. de Almeida L, et al. Immunity, 2015 Aug 18. PMID 26275995, Free PMC Article
    3. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Xiao S, et al. Annu Rev Biochem, 2002. PMID 12045094, Free PMC Article
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.
      Title: POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36536

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleolar ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonucleases P/MRP protein subunit POP1
    Names
    processing of precursors 1
    ribonucleases P/MRP protein subunit homolog
    NP_080616.1
    NP_690854.1
    XP_006520221.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026340.3 → NP_080616.1  ribonucleases P/MRP protein subunit POP1 isoform 2

      See identical proteins and their annotated locations for NP_080616.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK016547, BM204185, CN722321
      Consensus CDS
      CCDS27419.1
      UniProtKB/TrEMBL
      Q9D4G5
      Related
      ENSMUSP00000078037.6, ENSMUST00000079028.6
      Conserved Domains (2) summary
      pfam06978
      Location:107 → 257
      POP1; Ribonucleases P/MRP protein subunit POP1
      pfam08170
      Location:618 → 707
      POPLD; POPLD (NUC188) domain

    2. NM_152894.2 → NP_690854.1  ribonucleases P/MRP protein subunit POP1 isoform 1

      See identical proteins and their annotated locations for NP_690854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC126028, AK016547, BM204185, CN722321
      Consensus CDS
      CCDS27420.1
      UniProtKB/TrEMBL
      Q8K205
      Related
      ENSMUSP00000052654.8, ENSMUST00000052290.14
      Conserved Domains (2) summary
      pfam06978
      Location:107 → 257
      POP1; Ribonucleases P/MRP protein subunit POP1
      pfam08170
      Location:648 → 737
      POPLD; POPLD (NUC188) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34495457..34530799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520158.5 → XP_006520221.1  ribonucleases P/MRP protein subunit POP1 isoform X1

      Conserved Domains (1) summary
      pfam08170
      Location:110 → 201
      POPLD; POPLD (NUC188) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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