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    gbas-1 G-protein alpha subunit activating protein gbas-1 [ Caenorhabditis elegans ]

    Gene ID: 173603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gbas-1
    Official Full Name
    G-protein alpha subunit activating protein gbas-1
    Primary source
    WormBase:WBGene00019130
    Locus tag
    CELE_F59H5.1
    See related
    AllianceGenome:WB:WBGene00019130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables G-protein alpha-subunit binding activity and guanyl-nucleotide exchange factor activity. Involved in small GTPase-mediated signal transduction. Is expressed in several structures, including GLR; coelomocyte; distal tip cell; intestine; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gbas-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    13
    Sequence:
    Chromosome: II; NC_003280.10 (2504878..2514905)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation. DiGiacomo V, et al. Biochemistry, 2018 Jan 23. PMID 29035513, Free PMC Article
    2. Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation. Coleman BD, et al. Mol Biol Evol, 2016 Mar. PMID 26659249, Free PMC Article
    3. Proteins interacting with Caenorhabditis elegans Galpha subunits. Cuppen E, et al. Comp Funct Genomics, 2003. PMID 18629017, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein alpha subunit activating protein gbas-1
    NP_494285.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2504878..2514905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061884.7 → NP_494285.2  G-protein alpha subunit activating protein gbas-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494285.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86RS8, Q9TZI4
      Conserved Domains (2) summary
      smart00583
      Location:375 → 482
      SPK; domain in SET and PHD domain containing proteins and protein kinases
      cl11619
      Location:229 → 318
      SPK; Domain of unknown function (DUF545)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TZI4.2

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