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    F59E12.1 Bromo domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F59E12.1
    Official Full Name
    Bromo domain-containing protein
    Primary source
    WormBase:WBGene00019118
    Locus tag
    CELE_F59E12.1
    See related
    AllianceGenome:WB:WBGene00019118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be part of NuA4 histone acetyltransferase complex. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F59E12.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (5654515..5657371)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative serine/threonine-protein kinase zyg-1 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Alpha-(1,3)-fucosyltransferase fut-3 Neighboring gene Intraflagellar transport protein 43 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics. Baytek G, et al. Biotechniques, 2022 Jun. PMID 35698829
    2. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Bromo domain-containing protein
    NP_495105.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5654515..5657371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062704.4 → NP_495105.1  Bromo domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495105.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01905
      Conserved Domains (2) summary
      PHA03307
      Location:180 → 530
      PHA03307; transcriptional regulator ICP4; Provisional
      cl02556
      Location:642 → 744
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    Nucleotide Protein
    Heading Accession and Version

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