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    bcmo-2 Beta,beta-carotene 9',10'-oxygenase [ Caenorhabditis elegans ]

    Gene ID: 173733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bcmo-2
    Official Full Name
    Beta,beta-carotene 9',10'-oxygenase
    Primary source
    WormBase:WBGene00018755
    Locus tag
    CELE_F53C3.12
    See related
    AllianceGenome:WB:WBGene00018755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable beta-carotene 15,15'-dioxygenase activity and carotenoid dioxygenase activity. Predicted to be involved in carotene catabolic process and retinal metabolic process. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human BCO1 (beta-carotene oxygenase 1); BCO2 (beta-carotene oxygenase 2); and RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bcmo-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (3908490..3910837, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene CX domain-containing protein Neighboring gene CX domain-containing protein Neighboring gene FTH domain-containing protein Neighboring gene F-box associated domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans. Pan W, et al. Front Mol Biosci, 2022. PMID 35223999, Free PMC Article
    2. The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Li J, et al. Dev Biol, 2007 Jan 1. PMID 17098225, Free PMC Article
    3. daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan. Chen D, et al. PLoS Genet, 2014 Oct. PMID 25330189, Free PMC Article
    4. Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity. Arneaud SLB, et al. Aging Cell, 2022 Sep. PMID 35977034, Free PMC Article
    5. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-carotene 15,15'-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carotenoid dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carotene catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Beta,beta-carotene 9',10'-oxygenase
    NP_494694.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3908490..3910837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062293.7 → NP_494694.2  Beta,beta-carotene 9',10'-oxygenase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TXT9
      Conserved Domains (1) summary
      pfam03055
      Location:24 → 526
      RPE65; Retinal pigment epithelial membrane protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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