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    ssu-1 Sulfotransferase ssu-1 [ Caenorhabditis elegans ]

    Gene ID: 190959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ssu-1
    Official Full Name
    Sulfotransferase ssu-1
    Primary source
    WormBase:WBGene00013748
    Locus tag
    CELE_Y113G7A.11
    See related
    AllianceGenome:WB:WBGene00013748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables aryl sulfotransferase activity. Involved in sulfur compound metabolic process. Located in cytosol. Is expressed in ASJL and ASJR. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital ichthyosis 14; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ssu-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (20128287..20133263, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene tRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel sulfotransferase abundantly expressed in the dauer larvae of Caenorhabditis elegans. Hattori K, et al. J Biochem, 2006 Mar. PMID 16567400
    2. Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. Burton NO, et al. Nat Commun, 2018 Dec 4. PMID 30514845, Free PMC Article
    3. Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans. González-Barrios M, et al. Genetics, 2015 May. PMID 25769980, Free PMC Article
    4. Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans. Gómez-Escribano AP, et al. EMBO Rep, 2023 Jun 5. PMID 37103980, Free PMC Article
    5. Inhibition of Lithium-Sensitive Phosphatase BPNT-1 Causes Selective Neuronal Dysfunction in C. elegans. Meisel JD, et al. Curr Biol, 2016 Jul 25. PMID 27397889, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tthis cytosolic sulfotransferase (clone Y113G7A.11) either forms part of a defense system against xenobiotics or regulates germ cell proliferation in C. elegans.
      Title: A novel sulfotransferase abundantly expressed in the dauer larvae of Caenorhabditis elegans.
    2. unc-1, unc-24, and ssu-1 are neuronal stomatin-like proteins sharing regulatory roles with a sulfotransferase enzyme
      Title: Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfur compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sulfotransferase ssu-1
    NP_507880.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20128287..20133263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075479.2 → NP_507880.1  Sulfotransferase ssu-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507880.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U2Z2
      Conserved Domains (1) summary
      pfam00685
      Location:86 → 328
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U2Z2.1

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