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    parp-1 Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1 [ Caenorhabditis elegans ]

    Gene ID: 266823, updated on 9-Dec-2024

    Summary

    Official Symbol
    parp-1
    Official Full Name
    Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1
    Primary source
    WormBase:WBGene00004049
    Locus tag
    CELE_Y71F9AL.18
    See related
    AllianceGenome:WB:WBGene00004049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables NAD+-protein poly-ADP-ribosyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in nucleus. Predicted to be active in nucleolus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including arthritis; asthma; bacterial meningitis; neurodegenerative disease (multiple); and stomach carcinoma. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See parp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (2907730..2924713, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Coatomer subunit alpha Neighboring gene maleylacetoacetate isomerase Neighboring gene Tyrosine-protein phosphatase Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA (guanine(10)-N2)-methyltransferase homolog Neighboring gene Translocon-associated protein subunit alpha

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding  
    enables NAD binding  
    enables NAD+-protein ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity PubMed 
    enables glycosyltransferase activity  
    enables metal ion binding  
    enables nucleotidyltransferase activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in DNA repair  
    involved_in determination of adult lifespan PubMed 
    involved_in double-strand break repair  
    Component Evidence Code Pubs
    is_active_in nucleolus  
    located_in nucleus  

    General protein information

    Preferred Names
    Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1
    NP_001300471.1
    • Confirmed by transcript evidence
    NP_001300472.1
    • Confirmed by transcript evidence
    NP_001300473.1
    • Confirmed by transcript evidence
    NP_491072.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2907730..2924713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058671.11 → NP_491072.1  Poly [ADP-ribose] polymerase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZU4, Q9N4H4
      Conserved Domains (6) summary
      cd08001
      Location:465 → 570
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:5 → 943
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:586 → 938
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00645
      Location:13 → 90
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:314 → 368
      PADR1; PADR1 (NUC008) domain
      cl02166
      Location:236 → 272
      RRS1; Ribosome biogenesis regulatory protein (RRS1)
    2. NM_001313544.3 → NP_001300473.1  Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARD5
      Conserved Domains (2) summary
      cd01437
      Location:3 → 341
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:129 → 341
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    3. NM_001313543.3 → NP_001300472.1  Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWQ2
      Conserved Domains (2) summary
      cd01437
      Location:1 → 250
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:38 → 250
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    4. NM_001313542.3 → NP_001300471.1  Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUD3
      Conserved Domains (1) summary
      cl00283
      Location:11 → 81
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
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