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    daf-6 SSD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181584, updated on 9-Dec-2024

    Summary

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    Official Symbol
    daf-6
    Official Full Name
    SSD domain-containing protein
    Primary source
    WormBase:WBGene00000902
    Locus tag
    CELE_F31F6.5
    See related
    AllianceGenome:WB:WBGene00000902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of dauer larval development; and regulation of insulin receptor signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including cuticle; excretory system; interfacial epithelial cell; neurons; and vulval cell. Orthologous to human PTCHD3 (patched domain containing 3 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See daf-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (14888488..14894326)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sodium-dependent low-affinity dicarboxylate transporter 1 Neighboring gene Lipase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans.
      Title: DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans.
    2. Results suggest that the opposing daf-6 and lit-1 glial pathways act together to control sensory compartment size.
      Title: Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans.
    3. findings show that DAF-6 and intraflagellar transport modulate serotonin production in by remodeling the architecture of dendritic cilia of a pair of ADF serotonergic chemosensory neurons
      Title: Intraflagellar transport/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SSD domain-containing protein
    NP_510472.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14888488..14894326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078071.8 → NP_510472.2  SSD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510472.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19945
      Conserved Domains (1) summary
      pfam02460
      Location:49 → 901
      Patched; Patched family
    Nucleotide Protein
    Heading Accession and Version

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