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    • Showing Current items.

    agr-1 Agrin [ Caenorhabditis elegans ]

    Gene ID: 3565243, updated on 9-Dec-2024

    Summary

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    Official Symbol
    agr-1
    Official Full Name
    Agrin
    Primary source
    WormBase:WBGene00018304
    Locus tag
    CELE_F41G3.12
    See related
    AllianceGenome:WB:WBGene00018304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables dystroglycan binding activity. Located in basement membrane. Is expressed in hermaphrodite distal tip cell; hyp7 syncytium; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See agr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    29
    Sequence:
    Chromosome: II; NC_003280.10 (6760674..6775176, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FIS1-related protein fis-1 Neighboring gene FH2 domain-containing protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene RNA polymerase II subunit A C-terminal domain phosphatase ssup-72 Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans agrin is expressed in pharynx, IL1 neurons and distal tip cells and does not genetically interact with genes involved in synaptogenesis or muscle function. Hrus A, et al. PLoS One, 2007 Aug 15. PMID 17710131, Free PMC Article
    2. Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson's disease. Gaeta AL, et al. iScience, 2023 Jun 16. PMID 37260751, Free PMC Article
    3. The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification. Teuscher AC, et al. Matrix Biol Plus, 2019 Feb. PMID 33543001, Free PMC Article
    4. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that the interaction between agrin and dystroglycan may be conserved in C. elegans but this interaction does not play a role at the NMJ or in muscle in general.
      Title: C. elegans agrin is expressed in pharynx, IL1 neurons and distal tip cells and does not genetically interact with genes involved in synaptogenesis or muscle function.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dystroglycan binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Agrin
    NP_001022152.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6760674..6775176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026981.6 → NP_001022152.3  Agrin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022152.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG68
      Conserved Domains (3) summary
      smart00280
      Location:327 → 371
      KAZAL; Kazal type serine protease inhibitors
      cd00055
      Location:670 → 716
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1289 → 1450
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    Nucleotide Protein
    Heading Accession and Version

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