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    dnc-2 putative dynactin subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 175837, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dnc-2
    Official Full Name
    putative dynactin subunit 2
    Primary source
    WormBase:WBGene00001018
    Locus tag
    CELE_C28H8.12
    See related
    AllianceGenome:WB:WBGene00001018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including centrosomal and pronuclear rotation; establishment of mitotic spindle orientation; and pronuclear migration. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. Part of dynactin complex. Is expressed in several structures, including intestine; pharynx; seam cell; somatic nervous system; and tail. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See dnc-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5924396..5925754, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Tryptophan 2,3-dioxygenase Neighboring gene Uncharacterized protein Neighboring gene BCL7-like protein Neighboring gene Matrix metalloproteinase-A Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos. Skop AR, et al. Curr Biol, 1998 Oct 8. PMID 9778526, Free PMC Article
    2. RACK-1 directs dynactin-dependent RAB-11 endosomal recycling during mitosis in Caenorhabditis elegans. Ai E, et al. Mol Biol Cell, 2009 Mar. PMID 19158384, Free PMC Article
    3. lis-1 is required for dynein-dependent cell division processes in C. elegans embryos. Cockell MM, et al. J Cell Sci, 2004 Sep 1. PMID 15331665
    4. Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos. Zhang H, et al. J Cell Sci, 2008 Jan 15. PMID 18187449
    5. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Terasawa M, et al. Genes Cells, 2010 Nov. PMID 20964796, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosomal and pronuclear rotation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pronuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dynactin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative dynactin subunit 2
    NP_498286.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5924396..5925754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065885.8 → NP_498286.1  putative dynactin subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09248
      Conserved Domains (1) summary
      pfam04912
      Location:8 → 330
      Dynamitin; Dynamitin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09248.1

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