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    tyr-3 Putative tyrosinase-like protein tyr-3 [ Caenorhabditis elegans ]

    Gene ID: 172472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tyr-3
    Official Full Name
    Putative tyrosinase-like protein tyr-3
    Primary source
    WormBase:WBGene00009001
    Locus tag
    CELE_F21C3.2
    See related
    AllianceGenome:WB:WBGene00009001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and monooxygenase activity. Is expressed in head mesodermal cell. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to several human genes including DCT (dopachrome tautomerase) and TYR (tyrosinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tyr-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (7274282..7278573, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene Small integral membrane protein Neighboring gene ncRNA Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the evolution of metazoan tyrosinase gene family. Esposito R, et al. PLoS One, 2012. PMID 22536431, Free PMC Article
    2. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Sendoel A, et al. Nature, 2010 Jun 3. PMID 20520707, Free PMC Article
    3. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative tyrosinase-like protein tyr-3
    NP_492055.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7274282..7278573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059654.5 → NP_492055.2  Putative tyrosinase-like protein tyr-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492055.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19673
      Conserved Domains (3) summary
      PLN00052
      Location:512 → 550
      PLN00052; prolyl 4-hydroxylase; Provisional
      smart00254
      Location:634 → 667
      ShKT; ShK toxin domain
      pfam00264
      Location:135 → 320
      Tyrosinase; Common central domain of tyrosinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19673.5

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