mtm-6 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6;phosphatidylinositol-3,5-bisphosphate 3-phosphatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mtm-6
Official Full Name: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6;phosphatidylinositol-3,5-bisphosphate 3-phosphatase
Primary source: WormBase:WBGene00003478
Locus tag: CELE_F53A2.8
See related: AllianceGenome:WB:WBGene00003478
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphatase binding activity. Involved in several processes, including nematode larval development; phosphatidylinositol metabolic process; and pinocytosis. Located in apical plasma membrane and cytosol. Is expressed in several structures, including anal depressor muscle; coelomocyte; intestinal cell; preanal ganglion; and tail. Used to study centronuclear myopathy. Orthologous to human MTMR6 (myotubularin related protein 6); MTMR7 (myotubularin related protein 7); and MTMR8 (myotubularin related protein 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mtm-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (13347085..13355684)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstrated that MTM-6 and MTM-9 function as part of a complex to regulate an endocytic pathway that involves the Arf6 GTPase; defined protein domains required for MTM-6 activity.
Title: Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans.
a novel neuronal function for MTM-6.
Title: MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans.
The authors conclude that regulation of endosomal trafficking by the MTM-6/MTM-9 myotubularin complex is required for the retromer-dependent recycling of MIG-14/Wls and Wnt secretion.
Title: Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53A2.8 (e-PCR)
- UniSTS:306029

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pinocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6;phosphatidylinositol-3,5-bisphosphate 3-phosphatase

NP_001022602.1

Confirmed by transcript evidence

NP_499753.1

Confirmed by transcript evidence

NP_871680.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13347085..13355684

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027431.7 → NP_001022602.1 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022602.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ED68

Conserved Domains (3) summary

smart00064
Location:616 → 674

FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1

cd13210
Location:6 → 103

PH-GRAM_MTMR6-like; Myotubularian (MTM) related (MTMR) 7 and 8 proteins Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

pfam06602
Location:109 → 445

Myotub-related; Myotubularin-like phosphatase domain
NM_067352.7 → NP_499753.1 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499753.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ED68, Q69Z15

Conserved Domains (3) summary

smart00064
Location:618 → 676

FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1

cd13210
Location:6 → 103

PH-GRAM_MTMR6-like; Myotubularian (MTM) related (MTMR) 7 and 8 proteins Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

pfam06602
Location:111 → 447

Myotub-related; Myotubularin-like phosphatase domain
NM_181951.6 → NP_871680.1 phosphatidylinositol-3,5-bisphosphate 3-phosphatase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871680.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBF2

Conserved Domains (3) summary

smart00064
Location:724 → 782

FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1

cd14532
Location:237 → 540

PTP-MTMR6-like; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatases 6, 7, and 8

cl17171
Location:117 → 209

PH-like; Pleckstrin homology-like domain