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    cah-6 Carbonic anhydrase [ Caenorhabditis elegans ]

    Gene ID: 189049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cah-6
    Official Full Name
    Carbonic anhydrase
    Primary source
    WormBase:WBGene00000284
    Locus tag
    CELE_T28F2.3
    See related
    AllianceGenome:WB:WBGene00000284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in nervous system. Orthologous to human CA6 (carbonic anhydrase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cah-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (3628246..3631112)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Seven cysteines N-terminal domain-containing protein Neighboring gene Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 Neighboring gene Protein LAZ1;Vacuolar protein sorting-associated protein 13D Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a gene encoding carbonic anhydrase from Ostertagia ostertagi and quantitative measurement of expression during in vivo exsheathment. DeRosa AA, et al. Vet Parasitol, 2008 Jun 14. PMID 18400401
    2. Identification of a nuclear carbonic anhydrase in Caenorhabditis elegans. Sherman TA, et al. Biochim Biophys Acta, 2012 Apr. PMID 22245567, Free PMC Article
    3. Molecular and biochemical analysis of the α class carbonic anhydrases in Caenorhabditis elegans. Fasseas MK, et al. Mol Biol Rep, 2011 Mar. PMID 20842438
    4. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Carbonic anhydrase
    NP_491189.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3628246..3631112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058788.3 → NP_491189.1  Carbonic anhydrase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02637
      Conserved Domains (1) summary
      cd03122
      Location:56 → 304
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    Nucleotide Protein
    Heading Accession and Version

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