mnm-2 Zinc finger protein mnm-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mnm-2
Official Full Name: Zinc finger protein mnm-2
Primary source: WormBase:WBGene00003380
Locus tag: CELE_C10A4.8
See related: AllianceGenome:WB:WBGene00003380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of axon guidance. Located in nucleus. Is expressed in several structures, including intestine; neurons; rectum; spermathecal-uterine junction; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mnm-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (7422641..7424913, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study found that mnm-2 enhances the effects of many growth cone guidance mutations on these axons, suggesting that it performs a novel function during axon guidance; mnm-2 encodes a protein related to the Kruppel-like Factor protein family.
Title: The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krüppel-like zinc finger protein MNM-2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C10A4.8 (e-PCR)
- UniSTS:319022

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Zinc finger protein mnm-2

NP_509256.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7422641..7424913 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076855.5 → NP_509256.2 Zinc finger protein mnm-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509256.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17895

Conserved Domains (3) summary

sd00017
Location:170 → 190

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:224 → 246

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:183 → 207

zf-H2C2_2; Zinc-finger double domain