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    ddo-1 D-aspartate oxidase 1;FAD dependent oxidoreductase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddo-1
    Official Full Name
    D-aspartate oxidase 1;FAD dependent oxidoreductase domain-containing protein
    Primary source
    WormBase:WBGene00008127
    Locus tag
    CELE_C47A10.5
    See related
    AllianceGenome:WB:WBGene00008127
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables D-aspartate oxidase activity; D-glutamate oxidase activity; and FAD binding activity. Predicted to be involved in D-amino acid catabolic process. Predicted to be located in peroxisomal matrix. Predicted to be active in cytoplasm. Is expressed in hypodermis and intestinal cell. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ddo-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (17774246..17777227, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene Serpentine receptor class epsilon-21 Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class AB (class A-like) Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization of d-aspartate oxidase from Caenorhabditis elegans: its potential use in the determination of free d-glutamate in biological samples. Katane M, et al. Biochim Biophys Acta Proteins Proteom, 2020 Aug. PMID 32376478
    2. Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans. Saitoh Y, et al. Mol Cell Biol, 2012 May. PMID 22393259, Free PMC Article
    3. Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans. Katane M, et al. Chem Biodivers, 2010 Jun. PMID 20564561
    4. Caenorhabditis elegans has two genes encoding functional d-aspartate oxidases. Katane M, et al. FEBS J, 2007 Jan. PMID 17140416
    5. Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment. Katane M, et al. Biochimie, 2010 Oct. PMID 20603179

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biochemical characterization of d-aspartate oxidase from Caenorhabditis elegans: its potential use in the determination of free d-glutamate in biological samples.
      Title: Biochemical characterization of d-aspartate oxidase from Caenorhabditis elegans: its potential use in the determination of free d-glutamate in biological samples.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables D-amino-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-amino-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-aspartate oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-aspartate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-glutamate oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glutamate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-amino acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-amino acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in D-amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-aspartate oxidase 1;FAD dependent oxidoreductase domain-containing protein
    NP_001256757.1
    • Confirmed by transcript evidence
    NP_001367222.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      17774246..17777227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269828.3 → NP_001256757.1  D-aspartate oxidase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256757.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45307
      Conserved Domains (2) summary
      pfam01266
      Location:4 → 324
      DAO; FAD dependent oxidoreductase
      cl21454
      Location:154 → 278
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001380853.1 → NP_001367222.1  FAD dependent oxidoreductase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8JQS2
      Conserved Domains (1) summary
      pfam01266
      Location:4 → 172
      DAO; FAD dependent oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45307.2

    Gene LinkOut

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