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    skpo-2 ShKT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    skpo-2
    Official Full Name
    ShKT domain-containing protein
    Primary source
    WormBase:WBGene00015841
    Locus tag
    CELE_C16C8.2
    See related
    AllianceGenome:WB:WBGene00015841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See skpo-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (3431282..3436512, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene NEPrilysin metallopeptidase family Neighboring gene Neprilysin-11 Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of a peroxidase gene controlling body size in the entomopathogenic nematode Steinernema hermaphroditum. Schwartz HT, et al. Genetics, 2024 Feb 7. PMID 38078889, Free PMC Article
    2. The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification. Teuscher AC, et al. Matrix Biol Plus, 2019 Feb. PMID 33543001, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ShKT domain-containing protein
    NP_494540.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3431282..3436512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062139.8 → NP_494540.1  ShKT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91060
      Conserved Domains (3) summary
      cd09823
      Location:341 → 687
      peroxinectin_like; peroxinectin_like animal heme peroxidases
      smart00254
      Location:61 → 95
      ShKT; ShK toxin domain
      pfam03098
      Location:204 → 690
      An_peroxidase; Animal haem peroxidase
    Nucleotide Protein
    Heading Accession and Version

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