ftn-1 Ferritin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ftn-1
Official Full Name: Ferritin
Primary source: WormBase:WBGene00001500
Locus tag: CELE_C54F6.14
See related: AllianceGenome:WB:WBGene00001500
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity. Involved in intracellular iron ion homeostasis. Predicted to be active in cytoplasm. Is expressed in intestine and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in basal ganglia disease; hemochromatosis type 5; hyperferritinemia-cataract syndrome; and neurodegenerative disease (multiple). Orthologous to several human genes including FTH1 (ferritin heavy chain 1); FTHL17 (ferritin heavy chain like 17); and FTMT (ferritin mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ftn-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (7546468..7547579, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans.
Title: Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans.
Our findings imply that the insulin/IGF-1 signaling(IIS) and HIF pathways act together to regulate iron homeostasis in C. elegans. We suggest that IIS/DAF-16 regulation of ftn-1 modulates a trade-off between growth and stress resistance
Title: Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.
Activation of ftn-1 transcription by iron requires GATA protein and the iron-dependent element functions as an iron-dependent enhancer in intestine.
Title: An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C54F6.14 (e-PCR)
- UniSTS:316432

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferroxidase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ferritin

NP_504944.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

7546468..7547579 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072543.8 → NP_504944.2 Ferritin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504944.2

Status: REVIEWED

UniProtKB/TrEMBL

O16453

Conserved Domains (2) summary

cd01056
Location:9 → 166

Euk_Ferritin; eukaryotic ferritins

pfam00210
Location:13 → 154

Ferritin; Ferritin-like domain