daf-10 Intraflagellar transport protein 122 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: daf-10
Official Full Name: Intraflagellar transport protein 122 homolog
Primary source: WormBase:WBGene00000906
Locus tag: CELE_F23B2.4
See related: AllianceGenome:WB:WBGene00000906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including non-motile cilium assembly; positive regulation of dauer larval development; and receptor localization to non-motile cilium. Located in ciliary basal body. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 1. Orthologous to human IFT122 (intraflagellar transport 122). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See daf-10 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 19

Sequence:: Chromosome: IV; NC_003282.8 (9136933..9146211, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F23B2.4 (e-PCR)
- UniSTS:314114

F23B2.5 (e-PCR)
- UniSTS:318161

F23B2.13 (e-PCR)
- UniSTS:320511

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in cellular localization	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intraciliary retrograde transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor localization to non-motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle A	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle A	ISS Inferred from Sequence or Structural Similarity more info
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Intraflagellar transport protein 122 homolog

NP_501591.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9136933..9146211 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069190.4 → NP_501591.2 Intraflagellar transport protein 122 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501591.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFW7

Conserved Domains (4) summary

COG2319
Location:22 → 308

WD40; WD40 repeat [General function prediction only]

pfam13429
Location:590 → 731

TPR_15; Tetratricopeptide repeat

sd00039
Location:22 → 58

7WD40; WD40 repeat [structural motif]

cl02567
Location:22 → 303

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...