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    dyrb-1 Dynein light chain roadblock [ Caenorhabditis elegans ]

    Gene ID: 188872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyrb-1
    Official Full Name
    Dynein light chain roadblock
    Primary source
    WormBase:WBGene00012004
    Locus tag
    CELE_T24H10.6
    See related
    AllianceGenome:WB:WBGene00012004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Located in several cellular components, including cell cortex; microtubule cytoskeleton; and perinuclear region of cytoplasm. Is expressed in ciliated neurons and intestine. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1) and DYNLRB2 (dynein light chain roadblock-type 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dyrb-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (9106515..9107145, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative transcription elongation factor S-II Neighboring gene Uncharacterized protein Neighboring gene J domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein 53

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo. Kimura K, et al. Proc Natl Acad Sci U S A, 2011 Jan 4. PMID 21173218, Free PMC Article
    2. Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans. Couwenbergs C, et al. J Cell Biol, 2007 Oct 8. PMID 17908918, Free PMC Article
    3. Insights on UNC-104-dynein/dynactin interactions and their implications on axonal transport in Caenorhabditis elegans. Chen CW, et al. J Neurosci Res, 2019 Feb. PMID 30311677
    4. A role for dynein in the inhibition of germ cell proliferative fate. Dorsett M, et al. Mol Cell Biol, 2009 Nov. PMID 19752194, Free PMC Article
    5. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dyrb-1, is a potential subunit involved in dynein anchoring for centrosome centration and is required for organelle movement toward the minus end of the microtubules.
      Title: Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo.
    2. DYRB-1 physically associates with LIN-5 and GPR-1/2.
      Title: Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dynein light chain roadblock
    NP_495943.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9106515..9107145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063542.7 → NP_495943.1  Dynein light chain roadblock [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495943.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22752
      Conserved Domains (1) summary
      pfam03259
      Location:4 → 93
      Robl_LC7; Roadblock/LC7 domain
    Nucleotide Protein
    Heading Accession and Version

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