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    obr-2 Oxysterol binding protein;Oxysterol-binding protein [ Caenorhabditis elegans ]

    Gene ID: 180003, updated on 9-Dec-2024

    Summary

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    Official Symbol
    obr-2
    Official Full Name
    Oxysterol binding protein;Oxysterol-binding protein
    Primary source
    WormBase:WBGene00008832
    Locus tag
    CELE_F14H8.1
    See related
    AllianceGenome:WB:WBGene00008832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sterol binding activity. Predicted to be involved in lipid transport. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Orthologous to several human genes including OSBPL2 (oxysterol binding protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See obr-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (15011870..15014264, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MUTator Neighboring gene Protein hrde-2 Neighboring gene Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene SPX domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    2. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Oxysterol binding protein;Oxysterol-binding protein
    NP_001122917.1
    • Confirmed by transcript evidence
    NP_001256642.1
    • Confirmed by transcript evidence
    NP_506695.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15011870..15014264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074294.5 → NP_506695.2  Oxysterol-binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506695.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93485
      Conserved Domains (1) summary
      pfam01237
      Location:44 → 401
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001129445.5 → NP_001122917.1  Oxysterol-binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122917.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2D6P3
      Conserved Domains (1) summary
      pfam01237
      Location:34 → 391
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_001269713.3 → NP_001256642.1  Oxysterol binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G1K0Y0
      Conserved Domains (1) summary
      pfam01237
      Location:6 → 229
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version

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