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    scl-1 SCP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scl-1
    Official Full Name
    SCP domain-containing protein
    Primary source
    WormBase:WBGene00004742
    Locus tag
    CELE_F49E11.9
    See related
    AllianceGenome:WB:WBGene00004742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in determination of adult lifespan; response to UV; and response to heat. Predicted to be active in extracellular space. Orthologous to several human genes including PI15 (peptidase inhibitor 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (13056326..13057351)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein phosphatase Neighboring gene pseudo Neighboring gene SCP domain-containing protein Neighboring gene SCP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct and indirect transcriptional targets of DAF-16. Larsen PL. Sci Aging Knowledge Environ, 2003 Apr 30. PMID 12844535
    2. Toxicogenomic effects of nano- and bulk-TiO2 particles in the soil nematode Caenorhabditis elegans. Rocheleau S, et al. Nanotoxicology, 2015 May. PMID 25211548
    3. Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Ookuma S, et al. Curr Biol, 2003 Mar 4. PMID 12620193
    4. CAP protein superfamily members in Toxocara canis. Stroehlein AJ, et al. Parasit Vectors, 2016 Jun 24. PMID 27342979, Free PMC Article
    5. Aging: new targets, new functions. Patterson GI. Curr Biol, 2003 Apr 1. PMID 12676107

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Required for the extension of the life span of daf-2 and age-1 mutants, down-regulation reduces life span and stress resistance.
      Title: Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SCP domain-containing protein
    NP_502502.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13056326..13057351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070101.3 → NP_502502.1  SCP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20608
      Conserved Domains (1) summary
      smart00198
      Location:19 → 174
      SCP; SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
    Nucleotide Protein
    Heading Accession and Version

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