tbh-1 DOMON domain-containing protein;Tyramine beta-hydroxylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tbh-1
Official Full Name: DOMON domain-containing protein;Tyramine beta-hydroxylase
Primary source: WormBase:WBGene00006541
Locus tag: CELE_H13N06.6
See related: AllianceGenome:WB:WBGene00006541
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables tyramine-beta hydroxylase activity. Involved in octopamine biosynthetic process. Located in synapse. Is expressed in intestine; nervous system; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tbh-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (15500256..15504895, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H13N06.6 (e-PCR)
- UniSTS:307103

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables dopamine beta-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine beta-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables tyramine-beta hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in dopamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in norepinephrine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in octopamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in octopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DOMON domain-containing protein;Tyramine beta-hydroxylase

NP_001257264.1

Partially confirmed by transcript evidence

NP_001257265.1

Confirmed by transcript evidence

NP_001300365.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15500256..15504895 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001270336.3 → NP_001257265.1 Tyramine beta-hydroxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257265.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XTQ6

Conserved Domains (3) summary

pfam01082
Location:198 → 315

Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain

pfam03351
Location:30 → 143

DOMON; DOMON domain

pfam03712
Location:336 → 490

Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
NM_001270335.2 → NP_001257264.1 Tyramine beta-hydroxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257264.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C6KRQ4, Q9XTQ6

Conserved Domains (3) summary

pfam01082
Location:270 → 387

Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain

pfam03351
Location:102 → 215

DOMON; DOMON domain

pfam03712
Location:408 → 562

Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
NM_001313436.5 → NP_001300365.1 DOMON domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATC0

Conserved Domains (3) summary

smart00664
Location:51 → 182

DoH; Possible catecholamine-binding domain present in a variety of eukaryotic proteins

pfam01082
Location:219 → 337

Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain

pfam03712
Location:357 → 511

Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain