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    T28F3.5 acetyl-CoA carboxylase [ Caenorhabditis elegans ]

    Gene ID: 178510, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T28F3.5
    Official Full Name
    acetyl-CoA carboxylase
    Primary source
    WormBase:WBGene00012131
    Locus tag
    CELE_T28F3.5
    See related
    AllianceGenome:WB:WBGene00012131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acetyl-CoA carboxylase activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human ACACA (acetyl-CoA carboxylase alpha) and ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T28F3.5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (17294789..17300864)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Zinc transporter zipt-7.1 Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Intraflagellar transport associated protein 2 Neighboring gene pseudo Neighboring gene EGF-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-CoA carboxylase
    NP_001255934.2
    • Confirmed by transcript evidence
    NP_001255935.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17294789..17300864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269005.5 → NP_001255934.2  acetyl-CoA carboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255934.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUC3
      Conserved Domains (8) summary
      cd06850
      Location:653 → 718
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:30 → 518
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:647 → 719
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:30 → 149
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1115 → 1533
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:791 → 876
      ACC_central; Acetyl-CoA carboxylase, central region
      cl08365
      Location:404 → 511
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      cl17255
      Location:154 → 379
      ATP-grasp_4; ATP-grasp domain

    2. NM_001269006.2 → NP_001255935.1  acetyl-CoA carboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P655
      Conserved Domains (4) summary
      cd06850
      Location:653 → 718
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:30 → 518
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam01039
      Location:1115 → 1522
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:791 → 876
      ACC_central; Acetyl-CoA carboxylase, central region
    Nucleotide Protein
    Heading Accession and Version

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