madd-3 Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: madd-3
Official Full Name: Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3
Primary source: WormBase:WBGene00006517
Locus tag: CELE_E02H4.3
See related: AllianceGenome:WB:WBGene00006517
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; and vulval muscle. Orthologous to several human genes including CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See madd-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 13

Sequence:: Chromosome: X; NC_003284.9 (14284752..14296659, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MADD-3 LAMMER kinase antagonizes the p38-mediated endosomal trafficking of EVA-1 to the lysosome. In this way, MADD-3 ensures that sufficient levels of EVA-1 are present to guide muscle arm extension towards the source of the MADD-4 guidance cue.
Title: The MADD-3 LAMMER Kinase Interacts with a p38 MAP Kinase Pathway to Regulate the Display of the EVA-1 Guidance Receptor in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

E02H4.3 (e-PCR)
- UniSTS:321329

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3

NP_001355370.1

Confirmed by transcript evidence

NP_001355453.1

Confirmed by transcript evidence

NP_001368709.1

Partially confirmed by transcript evidence

NP_001380238.1

Confirmed by transcript evidence

NP_001380239.1

Confirmed by transcript evidence

NP_741928.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14284752..14296659 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171799.8 → NP_741928.1 putative dual specificity protein kinase madd-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741928.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDB2, G5EGK0

Conserved Domains (2) summary

cd14134
Location:538 → 863

PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

cl26464
Location:73 → 364

Atrophin-1; Atrophin-1 family
NM_001392883.1 → NP_001380239.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E026

Conserved Domains (1) summary

cd14134
Location:1 → 248

PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
NM_001368550.4 → NP_001355370.1 putative dual specificity protein kinase madd-3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14134
Location:244 → 572

PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
NM_001392884.1 → NP_001380238.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E4Y4

Conserved Domains (1) summary

cd14134
Location:1 → 251

PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
NM_001368549.4 → NP_001355453.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DR12

Conserved Domains (1) summary

cd14134
Location:244 → 569

PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
NM_001381143.1 → NP_001368709.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E657

Conserved Domains (2) summary

PHA03247
Location:73 → 364

PHA03247; large tegument protein UL36; Provisional

cd14134
Location:538 → 866

PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases