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    npp-13 Nuclear pore protein [ Caenorhabditis elegans ]

    Gene ID: 171774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-13
    Official Full Name
    Nuclear pore protein
    Primary source
    WormBase:WBGene00003799
    Locus tag
    CELE_Y37E3.15
    See related
    AllianceGenome:WB:WBGene00003799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of nuclear pore. Involved in several processes, including establishment of mitotic spindle orientation; mitotic chromosome centromere condensation; and nuclear pore complex assembly. Predicted to be located in membrane and nucleus. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-13 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    17
    Sequence:
    Chromosome: I; NC_003279.8 (2097346..2123443)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene IstB_IS21 domain-containing protein;Secreted protein;ethanolamine-phosphate cytidylyltransferase Neighboring gene ncRNA Neighboring gene Ig-like domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Solute carrier family 40 member Neighboring gene Dimethylglycine dehydrogenase, mitochondrial Neighboring gene Rx N-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans. Tam AS, et al. G3 (Bethesda), 2015 Nov 12. PMID 26564951, Free PMC Article
    2. Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans. Schetter A, et al. Dev Biol, 2006 Jan 15. PMID 16325795, Free PMC Article
    3. Integral nuclear pore proteins bind to Pol III-transcribed genes and are required for Pol III transcript processing in C. elegans. Ikegami K, et al. Mol Cell, 2013 Sep 26. PMID 24011592, Free PMC Article
    4. Nucleoporins NPP-10, NPP-13 and NPP-20 are required for HCP-4 nuclear import to establish correct centromere assembly. Ferreira J, et al. J Cell Sci, 2017 Mar 1. PMID 28122936
    5. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. D'Angelo MA, et al. Cell, 2009 Jan 23. PMID 19167330, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome centromere condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear pore protein
    NP_001293351.1
    • Confirmed by transcript evidence
    NP_740802.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2097346..2123443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170819.6 → NP_740802.1  Nuclear pore protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BKT9
      Conserved Domains (1) summary
      pfam04097
      Location:206 → 771
      Nic96; Nup93/Nic96

    2. NM_001306422.3 → NP_001293351.1  Nuclear pore protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M8Y9
      Conserved Domains (1) summary
      pfam04097
      Location:77 → 645
      Nic96; Nup93/Nic96

    RNA

    1. NR_131352.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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