npp-3 Nuclear Pore complex Protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npp-3
Official Full Name: Nuclear Pore complex Protein
Primary source: WormBase:WBGene00003789
Locus tag: CELE_K12D12.2
See related: AllianceGenome:WB:WBGene00003789
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be a structural constituent of nuclear pore. Involved in several processes, including establishment of mitotic spindle orientation; nuclear pore complex assembly; and positive regulation of nematode male tail tip morphogenesis. Predicted to be located in nucleus. Predicted to be part of nuclear pore inner ring. Is expressed in embryonic cell. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npp-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 16

Sequence:: Chromosome: II; NC_003280.10 (11865431..11874788, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NPP-3 and nucleoporins that are associated with it are lost from the nuclear envelope in the vicinity of centrosomes at the onset of mitosis.
Title: The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K12D12.2 (e-PCR)
- UniSTS:305677

K12D12.3 (e-PCR)
- UniSTS:321585

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore inner ring	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear Pore complex Protein

NP_496534.1

Product from WormBase gene class npp;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11865431..11874788 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064133.5 → NP_496534.1 Nuclear Pore complex Protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496534.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21436

Conserved Domains (1) summary

pfam11894
Location:24 → 1260

Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205