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    W07B8.4 Peptidase C1A papain C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    W07B8.4
    Official Full Name
    Peptidase C1A papain C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00021072
    Locus tag
    CELE_W07B8.4
    See related
    AllianceGenome:WB:WBGene00021072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See W07B8.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (1130112..1131930, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Saccharopine dehydrogenase-like C-terminal domain-containing protein;Sacchrp_dh_NADP domain-containing protein Neighboring gene Expressed conserved protein;PB1 domain-containing protein Neighboring gene ncRNA Neighboring gene Cathepsin B-like cysteine proteinase 5 Neighboring gene Peptidase C1A papain C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase C1A papain C-terminal domain-containing protein
    NP_001300213.1
    • Partially confirmed by transcript evidence
    NP_503382.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1130112..1131930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070981.7 → NP_503382.1  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16288
      Conserved Domains (1) summary
      cd02620
      Location:74 → 327
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

    2. NM_001313284.3 → NP_001300213.1  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVX9
      Conserved Domains (1) summary
      cl23744
      Location:4 → 132
      Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...
    Nucleotide Protein
    Heading Accession and Version

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