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    nhr-66 Nuclear hormone receptor family member nhr-66 [ Caenorhabditis elegans ]

    Gene ID: 177618, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-66
    Official Full Name
    Nuclear hormone receptor family member nhr-66
    Primary source
    WormBase:WBGene00003656
    Locus tag
    CELE_T09A12.4
    See related
    AllianceGenome:WB:WBGene00003656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including head ganglion; hypodermis; neurons; terminal bulb; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-66 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (8226331..8236602, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ion transport domain-containing protein Neighboring gene Glutathione peroxidase Neighboring gene Stress-associated endoplasmic reticulum protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AraC family transcriptional regulator Neighboring gene WAPL domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans. Nasrallah MA, et al. PLoS Pathog, 2023 Oct. PMID 37906605, Free PMC Article
    2. Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct. Lee K, et al. PLoS One, 2016. PMID 27618178, Free PMC Article
    3. Dual Role of an mps-2/KCNE-Dependent Pathway in Long-Term Memory and Age-Dependent Memory Decline. Fenyves BG, et al. Curr Biol, 2021 Feb 8. PMID 33259792
    4. A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions. Fuxman Bass JI, et al. Mol Syst Biol, 2016 Oct 24. PMID 27777270, Free PMC Article
    5. Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans. Zeng L, et al. PLoS Genet, 2021 Jul. PMID 34237064, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-66
    NP_001023369.1
    • Confirmed by transcript evidence
    NP_001294133.1
    • Confirmed by transcript evidence
    NP_001294134.1
    • Confirmed by transcript evidence
    NP_001294135.1
    • Confirmed by transcript evidence
    NP_001294136.1
    • Confirmed by transcript evidence
    NP_001368431.1
    • Confirmed by transcript evidence
    NP_001370926.1
    • Confirmed by transcript evidence
    NP_001379637.1
    • Confirmed by transcript evidence
    NP_741462.1
    • Confirmed by transcript evidence
    NP_741463.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8226331..8236602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171396.7 → NP_741462.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741462.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KYJ7, H2KYJ8, Q5W611, Q8MXH0, W6RQQ7, W6RRP4, W6RT69, W6RT76, W6RXQ9, W6SB62
      UniProtKB/TrEMBL
      Q9GTD9
      Conserved Domains (2) summary
      cd06960
      Location:269 → 346
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:474 → 654
      HOLI; Ligand binding domain of hormone receptors

    2. NM_171397.8 → NP_741463.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTE0
      Conserved Domains (2) summary
      cd06960
      Location:113 → 190
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:318 → 498
      HOLI; Ligand binding domain of hormone receptors

    3. NM_001392346.1 → NP_001379637.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTE0
      Conserved Domains (2) summary
      cd06960
      Location:62 → 139
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      pfam00104
      Location:263 → 463
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor

    4. NM_001307205.2 → NP_001294134.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294134.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTD9
      Conserved Domains (2) summary
      cd06960
      Location:267 → 344
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:472 → 652
      HOLI; Ligand binding domain of hormone receptors

    5. NM_001383139.1 → NP_001370926.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTE0
      Conserved Domains (2) summary
      cd06960
      Location:64 → 141
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      pfam00104
      Location:265 → 465
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor

    6. NM_001307206.3 → NP_001294135.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTD9
      Conserved Domains (2) summary
      cd06960
      Location:193 → 270
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:398 → 578
      HOLI; Ligand binding domain of hormone receptors

    7. NM_001028198.5 → NP_001023369.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTD9
      Conserved Domains (2) summary
      cd06960
      Location:195 → 272
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:400 → 580
      HOLI; Ligand binding domain of hormone receptors

    8. NM_001307207.3 → NP_001294136.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294136.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTE0
      Conserved Domains (2) summary
      cd06960
      Location:115 → 192
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:320 → 500
      HOLI; Ligand binding domain of hormone receptors

    9. NM_001380356.1 → NP_001368431.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTE0
      Conserved Domains (2) summary
      cd06960
      Location:53 → 130
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      pfam00104
      Location:254 → 454
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor

    10. NM_001307204.3 → NP_001294133.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTE0
      Conserved Domains (2) summary
      cd06960
      Location:55 → 132
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:260 → 440
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
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