moc-3 Molybdopterin-synthase sulfurtransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: moc-3
Official Full Name: Molybdopterin-synthase sulfurtransferase
Primary source: WormBase:WBGene00018357
Locus tag: CELE_F42G8.6
See related: AllianceGenome:WB:WBGene00018357
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable URM1 activating enzyme activity; nucleotidyltransferase activity; and sulfurtransferase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process; protein urmylation; and tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human MOCS3 (molybdenum cofactor synthesis 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See moc-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (8130561..8132232)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that loss-of-function mutations of moc-3 and dph-3 effectively suppress the Multivulva (Muv) phenotype of the lin-1(e1275, R175Opal) mutation
Title: Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42G8.6 (e-PCR)
- UniSTS:310291

F42G8.10 (e-PCR)
- UniSTS:317717

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables URM1 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin-synthase adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molybdopterin-synthase sulfurtransferase activity	IEA Inferred from Electronic Annotation more info
enables molybdopterin-synthase sulfurtransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfurtransferase activity	IEA Inferred from Electronic Annotation more info
enables thiosulfate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in Mo-molybdopterin cofactor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein urmylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA thio-modification	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble position uridine thiolation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Molybdopterin-synthase sulfurtransferase

NP_501359.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8130561..8132232

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068958.6 → NP_501359.1 Molybdopterin-synthase sulfurtransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501359.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44510

Conserved Domains (3) summary

PRK07878
Location:8 → 402

PRK07878; molybdopterin biosynthesis-like protein MoeZ; Validated

cd00757
Location:17 → 246

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

cd01526
Location:283 → 402

RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...