vhp-1 Tyrosine-protein phosphatase vhp-1;protein-tyrosine-phosphatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vhp-1
Official Full Name: Tyrosine-protein phosphatase vhp-1;protein-tyrosine-phosphatase
Primary source: WormBase:WBGene00006923
Locus tag: CELE_F08B1.1
See related: AllianceGenome:WB:WBGene00006923
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables JUN kinase phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of MAPK cascade; regulation of defense response to bacterium; and regulation of protein localization to nucleus. Acts upstream of with a negative effect on protein catabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in hypodermis; intestine; neurons; pharynx; and vulva. Orthologous to human DUSP16 (dual specificity phosphatase 16) and DUSP8 (dual specificity phosphatase 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vhp-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (5323276..5340829)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1.
Title: The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1.
Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress.
Title: Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress.
vhp-1 mediates a novel JNK-like signaling pathway in stress response.
Title: The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS2-8 (e-PCR)
- UniSTS:241933

F08B1.1 (e-PCR)
- UniSTS:309586

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables JUN kinase phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stress response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cadmium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to copper ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to unfolded protein	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to unfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Tyrosine-protein phosphatase vhp-1;protein-tyrosine-phosphatase

NP_001343753.1

Confirmed by transcript evidence

NP_001343755.1

Confirmed by transcript evidence

NP_001364748.1

Confirmed by transcript evidence

NP_001364848.1

Confirmed by transcript evidence

NP_001421842.1

Confirmed by transcript evidence

NP_494998.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5323276..5340829

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356833.4 → NP_001343753.1 protein-tyrosine-phosphatase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C380

Conserved Domains (2) summary

cd00127
Location:179 → 317

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:12 → 154

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
NM_001377798.2 → NP_001364748.1 Tyrosine-protein phosphatase vhp-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10038, Q8IG35, Q8ST18, Q8ST19

Conserved Domains (2) summary

cd01446
Location:8 → 150

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14568
Location:176 → 316

DSP_MKP_classIII; dual specificity phosphatase domain of class III mitogen-activated protein kinase phosphatase
NM_001434913.1 → NP_001421842.1 protein-tyrosine-phosphatase [Caenorhabditis elegans]

Status: REVIEWED
NM_062597.4 → NP_494998.1 Tyrosine-protein phosphatase vhp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494998.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10038

Conserved Domains (1) summary

cd00127
Location:124 → 262

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_001377799.2 → NP_001364848.1 Tyrosine-protein phosphatase vhp-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C318

Conserved Domains (1) summary

cd14568
Location:21 → 161

DSP_MKP_classIII; dual specificity phosphatase domain of class III mitogen-activated protein kinase phosphatase
NM_001356836.3 → NP_001343755.1 Tyrosine-protein phosphatase vhp-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3G0

Conserved Domains (1) summary

cd00127
Location:1 → 104

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...