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    kqt-1 Potassium voltage-gated channel subfamily KQT member 5 [ Caenorhabditis elegans ]

    Gene ID: 180933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kqt-1
    Official Full Name
    Potassium voltage-gated channel subfamily KQT member 5
    Primary source
    WormBase:WBGene00002233
    Locus tag
    CELE_C25B8.1
    See related
    AllianceGenome:WB:WBGene00002233
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables potassium channel activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; intracellular signal transduction; and potassium ion transport. Predicted to be located in plasma membrane and synapse. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in head neurons; pharyngeal muscle cell; and touch receptor neurons. Used to study developmental and epileptic encephalopathy and long QT syndrome. Human ortholog(s) of this gene implicated in auditory system disease (multiple); autistic disorder; autosomal dominant intellectual developmental disorder 46; and electroclinical syndrome (multiple). Orthologous to several human genes including KCNQ4 (potassium voltage-gated channel subfamily Q member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kqt-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (6619012..6627995)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Cathepsin B-like cysteine proteinase 6 Neighboring gene Claudin domain-containing protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation. Wei AD, et al. J Biol Chem, 2005 Jun 3. PMID 15797864
    2. Efficient isolation of targeted Caenorhabditis elegans deletion strains using highly thermostable restriction endonucleases and PCR. Wei A, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384612, Free PMC Article
    3. Potassium channels in C. elegans. Salkoff L, et al. WormBook, 2005 Dec 30. PMID 18050399, Free PMC Article
    4. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
    5. A new gene-finding tool: using the Caenorhabditis elegans operons for identifying functional partner proteins in human cells. Eichmüller S, et al. J Biol Chem, 2004 Feb 20. PMID 14615488

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Potassium voltage-gated channel subfamily KQT member 5
    NP_741819.1
    • Confirmed by transcript evidence
    NP_741820.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6619012..6627995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171709.6 → NP_741819.1  Potassium voltage-gated channel subfamily KQT member 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQC5
      Conserved Domains (3) summary
      pfam00520
      Location:173 → 379
      Ion_trans; Ion transport protein
      pfam03520
      Location:540 → 651
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:297 → 371
      Ion_trans_2; Ion channel

    2. NM_171710.7 → NP_741820.1  Potassium voltage-gated channel subfamily KQT member 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDN5
      Conserved Domains (3) summary
      pfam00520
      Location:125 → 331
      Ion_trans; Ion transport protein
      pfam03520
      Location:492 → 603
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:249 → 323
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version

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