mep-1 MOG interacting and ectopic P-granules protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mep-1
Official Full Name: MOG interacting and ectopic P-granules protein 1
Primary source: WormBase:WBGene00003218
Locus tag: CELE_M04B2.1
See related: AllianceGenome:WB:WBGene00003218
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA binding activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including gonad development; oocyte development; and vulval development. Located in nucleus. Is expressed in several structures, including alimentary system; anal region; germ line; head; and nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mep-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (11524642..11527954)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MOG-6 has a function distinct from that of prevailing cyclophilins and that its binding to MEP-1 is essential for germline sex determination.
Title: Roles of the C. elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates.
sumoylation of LIN-1 mediates an interaction with MEP-1 that contributes to transcriptional repression of genes that promote vulval cell fates
Title: Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
In animals lacking MEP-1, germline genes are derepressed in somatic cells, and Polycomb group and SET domain-related proteins promote this ectopic expression. MEP-1 interacts with the germline-protein PIE-1.
Title: MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M04B2.1 (e-PCR)
- UniSTS:307814

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadal mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MOG interacting and ectopic P-granules protein 1

NP_502173.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11524642..11527954

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069772.9 → NP_502173.2 MOG interacting and ectopic P-granules protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502173.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21502, Q95VF1

Conserved Domains (1) summary

PRK13108
Location:7 → 144

PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed