ogdh-2 Transketolase-like pyrimidine-binding domain-containing protein;putative 2-oxoadipate dehydrogenase complex component E1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ogdh-2
Official Full Name: Transketolase-like pyrimidine-binding domain-containing protein;putative 2-oxoadipate dehydrogenase complex component E1 homolog
Primary source: WormBase:WBGene00014098
Locus tag: CELE_ZK836.2
See related: AllianceGenome:WB:WBGene00014098
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity and thiamine pyrophosphate binding activity. Predicted to be involved in glycolytic process. Predicted to be located in mitochondrion. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ogdh-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 10

Sequence:: Chromosome: V; NC_003283.11 (12194507..12205494)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK836.1 (e-PCR)
- UniSTS:308312

ZK836.2 (e-PCR)
- UniSTS:308313

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables oxoglutarate dehydrogenase (succinyl-transferring) activity	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transketolase-like pyrimidine-binding domain-containing protein;putative 2-oxoadipate dehydrogenase complex component E1 homolog

NP_001256410.1

Confirmed by transcript evidence

NP_001256411.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12194507..12205494

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269481.4 → NP_001256410.1 putative 2-oxoadipate dehydrogenase complex component E1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256410.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23629

Conserved Domains (4) summary

PRK09404
Location:56 → 911

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:166 → 439

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:557 → 763

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16870
Location:770 → 910

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
NM_001269482.3 → NP_001256411.1 Transketolase-like pyrimidine-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256411.1

Status: REVIEWED

UniProtKB/TrEMBL

F5GUD7

Conserved Domains (1) summary

cl39092
Location:1 → 787

SucA; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]