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    vms-1 tRNA endonuclease vms-1 [ Caenorhabditis elegans ]

    Gene ID: 176141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vms-1
    Official Full Name
    tRNA endonuclease vms-1
    Primary source
    WormBase:WBGene00019457
    Locus tag
    CELE_K06H7.3
    See related
    AllianceGenome:WB:WBGene00019457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable endonuclease activity and metal ion binding activity. Predicted to be involved in ERAD pathway. Located in cytoplasm and dendrite. Is expressed in amphid neurons; head neurons; intestine; tail neurons; and ventral nerve cord. Orthologous to human ANKZF1 (ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vms-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (8088535..8091601)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Anaphase-promoting complex subunit 2 Neighboring gene Uncharacterized protein Neighboring gene GTP exchange factor for ARFs 1 Neighboring gene isopentenyl-diphosphate Delta-isomerase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A stress-responsive system for mitochondrial protein degradation. Heo JM, et al. Mol Cell, 2010 Nov 12. PMID 21070972, Free PMC Article
    2. Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. Gaeta AL, et al. PLoS Genet, 2022 Aug. PMID 35984862, Free PMC Article
    3. Functional genomics of the cilium, a sensory organelle. Blacque OE, et al. Curr Biol, 2005 May 24. PMID 15916950
    4. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
    5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA endonuclease vms-1
    NP_498765.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8088535..8091601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066364.8 → NP_498765.1  tRNA endonuclease vms-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498765.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34511
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34511.2

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