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    Y71H2AM.11 Peptidase M20 dimerization domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y71H2AM.11
    Official Full Name
    Peptidase M20 dimerization domain-containing protein
    Primary source
    WormBase:WBGene00022176
    Locus tag
    CELE_Y71H2AM.11
    See related
    AllianceGenome:WB:WBGene00022176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to several human genes including CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y71H2AM.11 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (2718230..2725092, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene protein-histidine N-methyltransferase Neighboring gene Transmembrane protein 132 homolog Neighboring gene tRNA-Pro Neighboring gene Cyclin N-terminal domain-containing protein Neighboring gene Ras-related protein Rab-18 Neighboring gene Carboxylesterase type B domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase M20 dimerization domain-containing protein
    NP_497606.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2718230..2725092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065205.8 → NP_497606.4  Peptidase M20 dimerization domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497606.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL46
      Conserved Domains (1) summary
      cd05676
      Location:7 → 472
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
    Nucleotide Protein
    Heading Accession and Version

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