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    prcc-1 Proline-rich protein PRCC [ Caenorhabditis elegans ]

    Gene ID: 178257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prcc-1
    Official Full Name
    Proline-rich protein PRCC
    Primary source
    WormBase:WBGene00008034
    Locus tag
    CELE_C39E9.11
    See related
    AllianceGenome:WB:WBGene00008034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in papillary renal cell carcinoma. Orthologous to human PRCC (proline rich mitotic checkpoint control factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prcc-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (13091187..13093795, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SAP domain-containing protein Neighboring gene Replication factor C subunit 3 Neighboring gene Dynein light intermediate chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5' splice site identity. Suzuki JMNGL, et al. PLoS Genet, 2022 Feb. PMID 35143478, Free PMC Article
    2. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5' splice site identity.
      Title: A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5' splice site identity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Proline-rich protein PRCC
    NP_502515.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13091187..13093795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070114.7 → NP_502515.1  Proline-rich protein PRCC [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18535
      Conserved Domains (1) summary
      pfam10253
      Location:306 → 405
      PRCC; Mitotic checkpoint regulator, MAD2B-interacting
    Nucleotide Protein
    Heading Accession and Version

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