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    nse-4 Non-structural maintenance of chromosomes element 4 [ Caenorhabditis elegans ]

    Gene ID: 186758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nse-4
    Official Full Name
    Non-structural maintenance of chromosomes element 4
    Primary source
    WormBase:WBGene00010409
    Locus tag
    CELE_H21P03.2
    See related
    AllianceGenome:WB:WBGene00010409
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in DNA repair. Predicted to be located in chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human EID3 (EP300 interacting inhibitor of differentiation 3) and NSMCE4A (NSE4 homolog A, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nse-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (11480846..11482437)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene putative manganese-transporting ATPase catp-8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HTH cro/C1-type domain-containing protein Neighboring gene ncRNA Neighboring gene Phosphatidylcholine:ceramide cholinephosphotransferase 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of NSE-4 Perturbs Genome Stability and DNA Repair in Caenorhabditis elegans. Odiba AS, et al. Int J Mol Sci, 2022 Jun 29. PMID 35806213, Free PMC Article
    2. Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis. Odiba AS, et al. Genetics, 2023 Oct 4. PMID 37579186, Free PMC Article
    3. SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans. Odiba AS, et al. DNA Repair (Amst), 2024 May. PMID 38507953
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Non-structural maintenance of chromosomes element 4
    NP_502167.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11480846..11482437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069766.5 → NP_502167.2  Non-structural maintenance of chromosomes element 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502167.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XTV3
      Conserved Domains (1) summary
      pfam08743
      Location:307 → 395
      Nse4_C; Nse4 C-terminal
    Nucleotide Protein
    Heading Accession and Version

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