ubr-5 E3 ubiquitin-protein ligase UBR5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubr-5
Official Full Name: E3 ubiquitin-protein ligase UBR5
Primary source: WormBase:WBGene00009460
Locus tag: CELE_F36A2.13
See related: AllianceGenome:WB:WBGene00009460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and protein polyubiquitination. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ubr-5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 29

Sequence:: Chromosome: I; NC_003279.8 (8828048..8838719, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition.
Title: UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition.
Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function.
Title: Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function.
Molecular and genetic analyses indicate that the loss of ubr-5 function suppresses defects caused by reduced signaling via GLP-1 or LIN-12.
Title: UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F36A2.13 (e-PCR)
- UniSTS:321444

STS1-157 (e-PCR)
- UniSTS:241644

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-ubiquitin ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase UBR5

NP_492389.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8828048..8838719 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059988.6 → NP_492389.1 E3 ubiquitin-protein ligase UBR5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492389.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDT9

Conserved Domains (4) summary

smart00396
Location:1202 → 1271

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00119
Location:2614 → 2941

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2576 → 2942

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam11547
Location:182 → 233

E3_UbLigase_EDD; E3 ubiquitin ligase EDD