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    wago-10 PAZ domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wago-10
    Official Full Name
    PAZ domain-containing protein
    Primary source
    WormBase:WBGene00020707
    Locus tag
    CELE_T22H9.3
    See related
    AllianceGenome:WB:WBGene00020707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wago-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (343428..347640)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ABC transporter domain-containing protein Neighboring gene ncRNA Neighboring gene DM domain-containing protein Neighboring gene Autophagy-related protein 9 Neighboring gene rRNA biogenesis protein RRP36

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Charlesworth AG, et al. Nucleic Acids Res, 2021 Sep 7. PMID 34329465, Free PMC Article
    2. Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis. Mazzetto M, et al. Genome Res, 2024 Feb 7. PMID 38164610, Free PMC Article
    3. A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions. Seroussi U, et al. Elife, 2023 Feb 15. PMID 36790166, Free PMC Article
    4. From early lessons to new frontiers: the worm as a treasure trove of small RNA biology. Youngman EM, et al. Front Genet, 2014. PMID 25505902, Free PMC Article
    5. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Yigit E, et al. Cell, 2006 Nov 17. PMID 17110334

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PAZ domain-containing protein
    NP_503177.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      343428..347640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070776.5 → NP_503177.1  PAZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TXN7
      Conserved Domains (3) summary
      cd02826
      Location:499 → 932
      Piwi-like; Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The ...
      cd02846
      Location:347 → 439
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      pfam16488
      Location:478 → 515
      ArgoL2; Argonaute linker 2 domain
    Nucleotide Protein
    Heading Accession and Version

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